COVID-19 related multisystem inflammatory syndrome in children (MIS-C) : a case series from a tertiary care pediatric hospital in Qatar

BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of coronavirus disease 2019 (COVID-19) in children, which is increasingly being reported worldwide. Here we report the first case series of 7 children diagnosed with MIS-C in Qatar.

METHODS: Clinical features and outcomes of COVID-19 positive patients admitted to Sidra Medicine, Qatar from June to October 2020, who met the WHO case definition for MIS-C were reviewed.

RESULTS: The mean age in our case series was 5.6 years, of which 71.4% were males. All patients were previously healthy but had a history of COVID-19 infection. Fever, rash, vomiting and abdominal pain were the most common symptoms (70-100%). The average hospitalization was 12.9 days with no case fatalities. Laboratory findings included lymphopenia and thrombocytopenia in most patients, as well as evidence of coagulopathy and elevated inflammatory markers such as C-reactive protein, ferritin and procalcitonin. Many patients (71.4%) required inotropic support in intensive care, while only one required respiratory support. Although all patients had elevated cardiac biomarkers, cardiovascular involvement was observed in 42.9% of patients with one patient developing a giant coronary aneurysm. All patients received intravenous immunoglobulin (IVIG) and 86% of patients received corticosteroids, with two patients requiring treatment with IL-1 inhibitors.

CONCLUSIONS: Our report is one of the first reports on MIS-C from Asia. Although clinical features and outcomes are not significantly different from those reported elsewhere, lack of case fatalities in our cohort may indicate that early recognition and prompt medical attention is necessary for a favorable outcome in MIS-C.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

BMC pediatrics - Vol. 21, No. 1 (2021), p. 267

Language:

English

Contributors:

Hasan, Mohammad Rubayet
Al Zubaidi, Khaled
Diab, Karim
Hejazi, Yahia
Bout-Tabaku, Sharon
Al-Adba, Buthaina
Al Maslamani, Eman
Janahi, Mohammad
Roscoe, Diane
Lopez, Andres Perez
Tang, Patrick

Urls:

Volltext

Keywords:

*COVID-19
Asia
COVID-19
Child
Child, Preschool
Female
Hospitals, Pediatric
Humans
Journal Article
Kawasaki disease
Male
Multisystem inflammatory syndrome (MIS-C)
Qatar
SARS-CoV-2
Systemic Inflammatory Response Syndrome
Tertiary Healthcare

Notes:

Date Completed 11.06.2021

Date Revised 12.06.2021

published: Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1186/s12887-021-02743-8

PMID:

34103044

PPN (Catalogue-ID):

NLM327668873