Pseudothrombocytopenia-A Review on Causes, Occurrence and Clinical Implications

Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

Journal of clinical medicine - Vol. 10, No. 4 (2021)

Language:

English

Contributors:

Lardinois, Benjamin
Favresse, Julien
Chatelain, Bernard
Lippi, Giuseppe
Mullier, François

Urls:

Volltext

Keywords:

Amikacin
Anticoagulants
COVID-19
Fluorescence
Hematimetry
Journal Article
Platelets
Pseudothrombocytopenia
Review

Notes:

Date Revised 03.03.2021

published: Electronic

Citation Status PubMed-not-MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.3390/jcm10040594

PMID:

33557431

PPN (Catalogue-ID):

NLM322227011