Severity of COVID-19 in hospitalized patients with and without atopic disease

© 2021 The Authors..

Background: Data from the 2009 influenza pandemic suggested asthma might protect from severe disease in hospitalized patients. Asthma does not appear to increase risk for hospitalization or mortality with COVID-19.

Objective: This study was undertaken to see if atopy actually protected those hospitalized with COVID-19.

Methods: Retrospective chart review on all patients testing positive for SARS-CoV-2 over 2 months at a major adult and pediatric tertiary referral center hospital. Charts were evaluated for history of atopic disease, as were the need for ICU admission, requirement for supplemental oxygen and/or intubation, and in hospital mortality.

Results: No significant differences in outcomes for patients (n = 275) based on atopic disease were noted: ICU admission, 43% versus 44.7% (atopic versus no atopic disease, respectively; p = 0.84); supplemental oxygen use, 79.1% versus 73.6% (p = 0.36); intubation rate, 35.8% versus 36.5% (p = 0.92); and mortality rate, 13.4% versus 20.7% (p = 0.19). More patients with atopic disease had COPD listed as a diagnosis in their chart (38.8% versus 17.3%, p < 0.001). COPD was associated with an increased rate of ICU admission (aOR = 2.22 (1.15, 4.30) p = 0.02) and intubation (aOR = 2.05 (1.07, 3.92) p = 0.03). After adjusting for COPD, patients with atopic disease had a trend for reduced mortality (aOR 0.55 (0.23, 1.28), p = 0.16), but those with asthma did not (p > 0.2).

Conclusion: Severity of COVID-19 in hospitalized patients does not differ based on atopic status. However, adjusting for presence of COPD led to a suggestion of possible reduced severity in patients with atopy but not asthma.

Media Type:

Electronic Article
Cover Image
cover

Year of Publication:

2021

Contained In:

The World Allergy Organization journal - Vol. 14, No. 2 (2021), p. 100508

Language:

English

Contributors:

Timberlake, Dylan T
Narayanan, Deepika
Ogbogu, Princess U
Raveendran, Rekha
Porter, Kyle
Scherzer, Rebecca
Prince, Benjamin
Grayson, Mitchell H

Urls:

Volltext

Keywords:

Asthma
Atopy
CDC, Centers for Disease Control and Prevention
COPD, Chronic Obstructive Pulmonary Disease
COVID-19
COVID-19, Coronavirus Disease 2019
CRP, C Reactive Peptide
Hospitalization
ICS, Inhaled corticosteroid
ICU, Intensive Care Unit
Il-6, Interleukin 6
Journal Article
LABA, Long acting beta agonist
NHANES, National Health and Nutrition Examination Survey
RAST, Radioallergosorbent test
RT-PCR, Real time polymerase chain reaction
SARS-CoV-2
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
Severity

Notes:

Date Revised 02.02.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.waojou.2021.100508

PMID:

33520082

PPN (Catalogue-ID):

NLM321855027