Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of CCP with a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours of admission to propensity score-matched controls cared for at a medical center in the Bronx, between April 13 to May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroids, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients <65 years, but data from controlled trials is needed to validate this finding and establish the effect of ageing on CCP efficacy.

Errataetall:

UpdateIn: JCI Insight. 2021 Jan 21;:. - PMID 33476300

Media Type:

Electronic Article

Year of Publication:

2020

Contained In:

medRxiv : the preprint server for health sciences - (04.12.2020)

Language:

English

Contributors:

Yoon, Hyun Ah
Bartash, Rachel
Gendlina, Inessa
Rivera, Johanna
Nakouzi, Antonio
Bortz, Robert H
Wirchnianski, Ariel S
Paroder, Monika
Fehn, Karen
Serrano-Rahman, Leana
Babb, Rachelle
Sarwar, Uzma N
Haslwanter, Denise
Laudermilch, Ethan
Florez, Catalina
Dieterle, M Eugenia
Jangra, Rohit K
Fels, J Maximilian
Tong, Karen
Mariano, Margarette C
Vergnolle, Olivia
Georgiev, George I
Herrera, Natalia G
Malonis, Ryan J
Quiroz, Jose A
Morano, Nicholas C
Krause, Gregory J
Sweeney, Joseph M
Cowman, Kelsie
Allen, Stephanie
Annam, Jayabhargav
Applebaum, Ariella
Barboto, Daniel
Khokhar, Ahmed
Lally, Brianna J
Lee, Audrey
Lee, Max
Malaviya, Avinash
Sample, Reise
Yang, Xiuyi A
Li, Yang
Ruiz, Rafael
Thota, Raja
Barnhill, Jason
Goldstein, Doctor Y
Uehlinger, Joan
Garforth, Scott J
Almo, Steven C
Lai, Jonathan R
Gil, Morayma Reyes
Fox, Amy S
Chandran, Kartik
Wang, Tao
Daily, Johanna P
Pirofski, Liise-Anne

Urls:

Volltext

Keywords:

Preprint

Notes:

Date Revised 22.02.2021

published: Electronic

UpdateIn: JCI Insight. 2021 Jan 21;:. - PMID 33476300

Citation Status PubMed-not-MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1101/2020.12.02.20242909

PMID:

33300012

PPN (Catalogue-ID):

NLM319661180