Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved..

BACKGROUND: Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes with viral infections than people without obstructive disease.

OBJECTIVE: To evaluate if obstructive diseases are risk factors for intensive care unit (ICU) stay and death due to coronavirus disease 2019 (COVID19).

METHODS: We collected data from the electronic medical record from 596 adult patients hospitalized in University Hospital of Liege between March 18 and April 17, 2020, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. We classified patients into 3 groups according to the underlying respiratory disease, present before the COVID19 pandemic.

RESULTS: Among patients requiring hospitalization for COVID19, asthma and COPD accounted for 9.6% and 7.7%, respectively. The proportions of asthmatics, patients with COPD, and patients without obstructive airway disease hospitalized in the ICU were 17.5%, 19.6%, and 14%, respectively. One-third of patients with COPD died during hospitalization, whereas only 7.0% of asthmatics and 13.6% of patients without airway obstruction died due to SARS-CoV2. The multivariate analysis showed that asthma, COPD, inhaled corticosteroid treatment, and oral corticosteroid treatment were not independent risk factors for ICU admission or death. Male gender (odds ratio [OR]: 1.9; 95% confidence interval [CI]: 1.1-3.2) and obesity (OR: 8.5; 95% CI: 5.1-14.1) were predictors of ICU admission, whereas male gender (OR 1.9; 95% CI: 1.1-3.2), older age (OR: 1.9; 95% CI: 1.6-2.3), cardiopathy (OR: 1.8; 95% CI: 1.1-3.1), and immunosuppressive diseases (OR: 3.6; 95% CI: 1.5-8.4) were independent predictors of death.

CONCLUSION: Asthma and COPD are not risk factors for ICU admission and death related to SARS-CoV2 infection.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

The journal of allergy and clinical immunology. In practice - Vol. 9, No. 1 (2021), p. 160-169

Language:

English

Contributors:

Calmes, Doriane
Graff, Sophie
Maes, Nathalie
Frix, Anne-Noëlle
Thys, Marie
Bonhomme, Olivier
Berg, Julien
Debruche, Mathieu
Gester, Fanny
Henket, Monique
Paulus, Virginie
Duysinx, Bernard
Heinen, Vincent
Dang, Delphine Nguyen
Paulus, Astrid
Quaedvlieg, Valérie
Vaillant, Frederique
Van Cauwenberge, Hélène
Malaise, Michel
Gilbert, Alisson
Ghuysen, Alexandre
Gillet, Pierre
Moutschen, Michel
Misset, Benoit
Sibille, Anne
Guiot, Julien
Corhay, Jean-Louis
Louis, Renaud
Schleich, Florence

Urls:

Volltext

Keywords:

Asthma
COPD
COVID19
Death
ICU
Journal Article
Risk factors
SARS-CoV2
Severe asthma
Viral infection

Notes:

Date Revised 13.01.2021

published: Print-Electronic

Citation Status In-Process

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.jaip.2020.09.044

PMID:

33038592

PPN (Catalogue-ID):

NLM317055364