Corticosteroids as adjunctive therapy in the treatment of coronavirus disease 2019 : A report of two cases and literature review

Copyright © 2020. Published by Elsevier Ltd..

The effect of systemic corticosteroids on clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains controversial. While the use of corticosteroids raises concerns regarding delayed viral clearance, secondary infections, and long-term complications that can lead to increased mortality, corticosteroids have the potential to reduce mortality if used appropriately. Herein, we report good outcomes in two patients with COVID-19 who received systemic corticosteroids as adjunctive therapy. An 83-year-old man with hypertension and smoking history and a 62-year-old man with a drinking habit were transferred to our hospital with a diagnosis of COVID-19. The patients developed general malaise and loss of appetite with persistent high fever. Despite the prescription of antiviral drugs, their hypoxemia progressed rapidly. However, after the introduction of systemic corticosteroids, their symptoms improved as the fever decreased, and their hypoxemia gradually improved. These results suggest that some patients with COVID-19 may benefit from the appropriate use of systemic corticosteroids as adjunctive therapy.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - Vol. 27, No. 1 (2021), p. 94-98

Language:

English

Contributors:

Kosaka, Makoto
Yamazaki, Yoshitaka
Maruno, Takashi
Sakaguchi, Koji
Sawaki, Shoji

Urls:

Volltext

Keywords:

Acute respiratory distress syndrome
Adrenal Cortex Hormones
Aged, 80 and over
Alcohol Drinking
Antiviral Agents
Betacoronavirus
COVID-19
Case Reports
Combined Modality Therapy
Coronavirus Infections
Coronavirus disease 2019
Corticosteroids
Humans
Hypertension
Journal Article
Lung
Male
Methylprednisolone
Middle Aged
Pandemics
Pneumonia, Viral
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Smoking
Stomach Neoplasms
Tomography, X-Ray Computed
Treatment Outcome
X4W7ZR7023

Notes:

Date Completed 23.11.2020

Date Revised 10.01.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.jiac.2020.09.007

PMID:

32988730

PPN (Catalogue-ID):

NLM316557358