Smell and taste alterations in COVID-19 : a cross-sectional analysis of different cohorts

© 2020 ARS-AAOA, LLC..

BACKGROUND: Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs to be clarified.

METHODS: A cross-sectional study was performed from March 27 to April 1, 2020, in Northern Italy. Physicians administered a survey-based questionnaire to SARS-CoV-2-positive patients with the aim of assessing symptoms, focusing on OD and GD. Two groups were studied: group A, patients hospitalized at Azianda Socio Sanitaria Territoriale (ASST) Spedali Civili University Hospital of Brescia; and group B, home-quarantined subjects.

RESULTS: A total of 508 patients were enrolled: 295 in group A and 213 in group B. Mean age ± standard deviation (SD) was 55 ± 15 years; 56% were men. Overall, OD and GD were present in 56% (95% confidence interval [CI], 51% to 60%) and 63% (95% CI, 59% to 67%) of cases, respectively. In group A, the prevalence of OD and GD was 44% (95% CI, 38% to 50%) and 52% (95% CI, 46% to 58%), respectively. In group B, the prevalence of OD and GD was 72% (95% CI, 65% to 79%) and 79% (95% CI, 73% to 84%), respectively. In the entire cohort, total loss of olfaction and taste was reported in 64% and 60% of cases, respectively. OD and GD occurred as the first symptom in 10% and 11% of cases, respectively; in the remaining cases, they occurred after a mean of 4 ± 3 days following the first symptom. At the time of the questionnaire, complete resolution of OD and GD was reported in 52% and 55% of cases, respectively (mean duration, 9 ± 5 days in both).

CONCLUSION: OD and GD are more prevalent in home-quarantined subjects, and they are independently associated with younger age and female gender.

Media Type:

Electronic Article

Year of Publication:

2020

Contained In:

International forum of allergy & rhinology - Vol. 10, No. 8 (2020), p. 955-962

Language:

English

Contributors:

Paderno, Alberto
Schreiber, Alberto
Grammatica, Alberto
Raffetti, Elena
Tomasoni, Michele
Gualtieri, Tommaso
Taboni, Stefano
Zorzi, Silvia
Lombardi, Davide
Deganello, Alberto
Redaelli De Zinis, Luca Oscar
Maroldi, Roberto
Mattavelli, Davide

Links:

Volltext

Keywords:

*Coronavirus Infections
*Dysgeusia
*Olfaction Disorders
*Pandemics
*Pneumonia, Viral
Age Factors
Betacoronavirus
COVID-19
Cross-Sectional Studies
Female
Gustatory dysfunction
Humans
Italy
Journal Article
Male
Middle Aged
Olfactory dysfunction
Prevalence
Recovery of Function
SARS-CoV-2
Sex Factors
Smell
Symptom Assessment
Taste

Notes:

Date Completed 12.08.2020

Date Revised 12.08.2020

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1002/alr.22610

PMID:

32410386

PPN (Catalogue-ID):

NLM310800269