Vitamin D deficiency in a European inflammatory bowel disease inception cohort : an Epi-IBD study

BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.

MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.

RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).

CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.

Media Type:

Electronic Article

Year of Publication:

2018

Contained In:

European journal of gastroenterology & hepatology - Vol. 30, No. 11 (2018), p. 1297-1303

Language:

English

Contributors:

Chetcuti Zammit, Stefania
Ellul, Pierre
Girardin, Giulia
Valpiani, Daniela
Nielsen, Kári R
Olsen, Jóngerð
Goldis, Adrian
Lazar, Daniela
Shonová, Olga
Nováková, Marie
Sebastian, Shaji
Whitehead, Emma
Carmona, Amalia
Martinez-Cadilla, Jesus
Dahlerup, Jens F
Kievit, Adriana L H
Thorsgaard, Niels
Katsanos, Konstantinos H
Christodoulou, Dimitrios K
Magro, Fernando
Salupere, Riina
Pedersen, Natalia
Kjeldsen, Jens
Carlsen, Katrine
Ioannis, Kaimaklioti
Bergemalm, Daniel
Halfvarson, Jonas
Duricova, Dana
Bortlik, Martin
Collin, Pekka
Oksanen, Pia
Kiudelis, Gediminas
Kupcinskas, Limas
Kudsk, Karen
Andersen, Vibeke
O'Morain, Colm
Bailey, Yvonne
Doron, Schwartz
Shmuel, Odes
Almer, Sven
Arebi, Naila
Misra, Ravi
Čuković-Čavka, Silvija
Brinar, Marko
Munkholm, Pia
Vegh, Zsuzsanna
Burisch, Johan

Urls:

Volltext

Keywords:

1406-16-2
Adolescent
Adrenal Cortex Hormones
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents
Biomarkers
Child
Europe
Female
Humans
Inflammatory Bowel Diseases
Journal Article
Male
Middle Aged
Multicenter Study
Prevalence
Quality of Life
Risk Factors
Severity of Illness Index
Smoking
Time Factors
Vitamin D
Vitamin D Deficiency
Young Adult

Notes:

Date Completed 28.01.2019

Date Revised 28.01.2019

published: Print

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1097/MEG.0000000000001238

PMID:

30134383

PPN (Catalogue-ID):

NLM288117980