The Italian Registry of Therapeutic Apheresis : granulocyte-monocyte apheresis in the treatment of inflammatory bowel disease. A multicentric study

Copyright © 2011 Wiley Periodicals, Inc..

Leukocytes are thought to play an important role in the pathogenesis of inflammatory bowel diseases; granulocyte-monocyte adsorptive (GMA) apheresis, an extracorporeal technique aimed at removing activated circulating leukocytes from the blood, may represent a safe and effective therapeutic tool in these patients. The Italian Registry of Therapeutic Apheresis performed an observational, multicentric study involving 24 Gastroenterology Units. In this study, laboratory data and clinical outcomes of 230 patients (148 males, mean age 43.5 years) affected with ulcerative colitis (UC, n = 194) or Crohn's disease (CD, n = 36) who underwent one or more cycles of GMA were analyzed. Each cycle consisted of five GMA treatments. The patients were followed up for a mean of 8.7 (min. 3 to max. 12) months. At 3 months, positive outcome was achieved in 77.7% of UC patients (72.0% remission, 5.7% clinical response) and 61.3% of CD patients (54.8% remission, 6.5% clinical response). The cumulative proportion of positive outcome at 12 months was 87.1% for UC patients (83.7% remission, 3.4% clinical response) and 77.4% for CD patients (74.2% remission, 3.2% clinical response). No single clinical or laboratory parameter among those analyzed (age, sex, disease characteristics, history of smoking, medication history, baseline values of clinical activity index (CAI)/Crohn's disease activity index (CDAI), hemoglobin, white blood cells count, and erythrocyte sedimentation rate) was independently associated with clinical outcome. The procedure was well tolerated with no significant adverse effects registered.

Media Type:

Electronic Article
Cover Image
cover

Year of Publication:

2011

Contained In:

Journal of clinical apheresis - Vol. 26, No. 6 (2011), p. 332-7

Language:

English

Contributors:

Passalacqua, Stefano
Ferraro, Pietro Manuel
Bresci, Giampaolo
D'Ovidio, Valeria
Astegiano, Marco
Principi, Mariabeatrice
Testa, Roberto
D'Incà, Renata
Valpiani, Daniela
Armuzzi, Alessandro
Sablich, Renato
Cavallaro, Flaminia
Costa, Francesco
Di Leo, Vincenza
Colombo, Elisabetta
Santini, Alessia
Aratari, Annalisa
Lecis, Pierenrico
Saladino, Valeria
Riegler, Gabriele
Marco, Marino
Calella, Francesca
Ricci, Chiara
Guidi, Maria Luisa
Repaci, Giuseppe
Silla, Michele

Urls:

Volltext

Keywords:

Adolescent
Adult
Aged
Colitis, Ulcerative
Crohn Disease
Female
Follow-Up Studies
Granulocytes
Humans
Inflammatory Bowel Diseases
Italy
Journal Article
Leukapheresis
Male
Middle Aged
Monocytes
Multicenter Study
Registries
Remission Induction
Research Support, Non-U.S. Gov't
Treatment Outcome
Young Adult

Notes:

Date Completed 17.04.2012

Date Revised 14.12.2011

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1002/jca.20315

PMID:

22072543

PPN (Catalogue-ID):

NLM212915061